论文标题
非典型的GC碱基对和DNA的机械化学裂解
Non-Canonical GC Base Pairs and Mechanochemical Cleavage of DNA
论文作者
论文摘要
分析了非经典GC碱基对的性能及其与DNA的机械化学裂解的关系。提出了瞬态GC摇摆基碱对在DNA和表观遗传机理的机械化学裂解中的参与的假设，并提出了5-甲基胞嘧啶的参与。该假设解释了细胞氨酸后DNA糖磷酸主链断裂的频率的增加，这些断裂的不对称特征以及胞质甲基化后CPG中断裂频率的增加。
Properties of non-canonical GC Base Pairs and their relation with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the Transient GC Wobble Base Pairs in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms with participation of 5-methylcytosine is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, asymmetric character of these breaks, and an increase in the frequency of breaks in CpG after cytosine methylation.
