论文标题
介孔二氧化硅封装的金纳米棒在化学热治疗中载有阿霉素的金纳米棒
Applications of mesoporous silica encapsulated gold nanorods loaded doxorubicin in chemo-photothermal therapy
论文作者
论文摘要
我们研究了使用介孔二氧化硅（MSIO2）加载阿霉素（DOX）涂覆的金纳米棒（GNRS）的化学效应作用。当介孔二氧化硅层被阿霉素药物嵌入时，吸收光谱的显着变化可以量化药物载荷。我们对具有GNRS@MSIO2和GNRS@MSIO2-DOX的小鼠的盐水和肝脏进行光热实验。我们还将金纳米结构注入了许多肿瘤植入的小鼠，并在其中一些小鼠上使用激光照明。通过测量肿瘤的体重和大小，可以确定光热疗法和化学疗法的明显效率。我们通过实验证实肝脏中金纳米结构的积累。
We investigate chemo-photothermal effects of gold nanorods (GNRs) coated using mesoporous silica (mSiO2) loading doxorubicin (DOX). When the mesoporous silica layer is embedded by doxorubicin drugs, a significant change in absorption spectra enable to quantify the drug loading. We carry out photothermal experiments on saline and livers of mice having GNRs@mSiO2 and GNRs@mSiO2-DOX. We also inject the gold nanostructures into many tumor-implanted mice and use laser illumination on some of them. By measuring weight and size of tumors, the distinct efficiency of photothermal therapy and chemotherapy on treatment is determined. We experimentally confirm the accumulation of gold nanostructures in liver.
