论文标题
纯机械模型，具有不对称特征，用于早期形态发生，棒状细菌微颜色
A purely mechanical model with asymmetric features for early morphogenesis of rod-shaped bacteria micro-colony
论文作者
论文摘要
为了模拟棒状细菌微颜色的形态发生，在生物物理文献中提出了几种基于个体的模型。在研究微色的形状时，大多数模型都会呈现相互作用的力，例如吸引力或录制链接。在本文中，我们提出了一个模型，其中细菌仅通过非重叠的约束相互作用。我们考虑细菌的不对称性及其对底物摩擦的影响。此外，我们考虑细菌沿其长度的质量分布中的不对称性。这两个新的建模假设使我们能够检索微颜色生长的机械行为，而无需相互作用（例如吸引力）。我们将模型与各种实验集进行比较，讨论我们的结果，并提出了几个量化符，以系统的方式将模型与数据进行比较。
To model the morphogenesis of rod-shaped bacterial micro-colony, several individual-based models have been proposed in the biophysical literature. When studying the shape of micro-colonies, most models present interaction forces such as attraction or filial link. In this article, we propose a model where the bacteria interact only through non-overlapping constraints. We consider the asymmetry of the bacteria, and its influence on the friction with the substrate. Besides, we consider asymmetry in the mass distribution of the bacteria along their length. These two new modelling assumptions allow us to retrieve mechanical behaviours of micro-colony growth without the need of interaction such as attraction. We compare our model to various sets of experiments, discuss our results, and propose several quantifiers to compare model to data in a systematic way.
