论文标题
在生物离子通道中选择性传导和点突变的物理学
Physics of selective conduction and point mutation in biological ion channels
论文作者
论文摘要
我们引入了具有多个结合位点和可能的点突变的生物离子通道中选择性传导的统计和线性响应理论。我们为选择性滤波器提供了有效的大典型集合和广义的爱因斯坦关系，假设具有强烈协调的离子运动，并允许离子库仑阻塞。该理论与来自KCSA K $^+$通道和突变体的数据非常吻合。我们表明，热力学选择性的Eisenman关系来自快速传导的条件，发现最大传导需要结合位点几乎相同。
We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutations. We derive an effective grand-canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K$^+$ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical.
