论文标题
用于功能连接分析的稀疏对称张量回归
Sparse Symmetric Tensor Regression for Functional Connectivity Analysis
论文作者
论文摘要
张量回归模型,例如CP回归和Tucker回归,在神经成像分析中具有许多成功的应用,在神经影像分析中,协变量具有超高维度并具有复杂的空间结构。高维的协变量阵列(也称为张量)可以通过低级别结构近似,并拟合到广义线性模型中。由此产生的张量回归可显着降低维度,同时在估计和预测方面保持有效。脑功能连通性是对大脑活动的重要度量,并且与阿尔茨海默氏病等神经系统疾病显示出显着关联。功能连接性的对称性质是在以前的张量回归模型中尚未探索的属性。在这项工作中,我们提出了一种稀疏的对称张量回归,该回归进一步减少了在各种模拟设置下,自由参数的数量和超过对称和普通CP回归的优越性能。我们将提出的方法应用于对伯克利衰老队列研究(BAC)(BAC)的阿尔茨海默氏病(AD)和正常衰老的研究,并检测到对AD很重要的两个感兴趣区域。
Tensor regression models, such as CP regression and Tucker regression, have many successful applications in neuroimaging analysis where the covariates are of ultrahigh dimensionality and possess complex spatial structures. The high-dimensional covariate arrays, also known as tensors, can be approximated by low-rank structures and fit into the generalized linear models. The resulting tensor regression achieves a significant reduction in dimensionality while remaining efficient in estimation and prediction. Brain functional connectivity is an essential measure of brain activity and has shown significant association with neurological disorders such as Alzheimer's disease. The symmetry nature of functional connectivity is a property that has not been explored in previous tensor regression models. In this work, we propose a sparse symmetric tensor regression that further reduces the number of free parameters and achieves superior performance over symmetrized and ordinary CP regression, under a variety of simulation settings. We apply the proposed method to a study of Alzheimer's disease (AD) and normal ageing from the Berkeley Aging Cohort Study (BACS) and detect two regions of interest that have been identified important to AD.