论文标题
蛋白质温度计的精度
Precision of protein thermometry
论文作者
论文摘要
温度传感是一种无处不在的细胞行为，但是对温度感应精度的基本限制知之甚少。与化学浓度传感不同，温度传感的精度不受温度场本身的外在波动的限制。取而代之的是，我们发现精度受到温度敏感蛋白的内在拷贝数，周转和结合动力学的限制。开发基于规范TLPA蛋白的模型，我们发现细胞可以估计温度在2％以内。我们将这种预测与细菌温度传感的体内数据进行比较。
Temperature sensing is a ubiquitous cell behavior, but the fundamental limits to the precision of temperature sensing are poorly understood. Unlike in chemical concentration sensing, the precision of temperature sensing is not limited by extrinsic fluctuations in the temperature field itself. Instead, we find that precision is limited by the intrinsic copy number, turnover, and binding kinetics of temperature-sensitive proteins. Developing a model based on the canonical TlpA protein, we find that a cell can estimate temperature to within 2%. We compare this prediction with in vivo data on temperature sensing in bacteria.
