论文标题
效果大小测量的比较，用于调解生存结果的调解分析与弗雷明汉心脏研究的应用
Comparison of Effect Size Measures for Mediation Analysis of Survival Outcomes with Application to the Framingham Heart Study
论文作者
论文摘要
在生存结果中调解分析研究的趋势越来越大。这样的分析有助于研究人员更好地了解暴露如何通过调解人影响疾病的结果。但是，由于对生存结果的审查观察结果，将调解分析从线性模型扩展到生存结果并不是一件直接的。在本文中，我们将基于$ r^2 $线性回归中的调解效应尺寸度量扩展到生存结果。由于生存模型的$ r^2 $的多个定义，我们比较和评估了五个$ r^2 $的调解分析措施。基于广泛的模拟，我们建议使用具有良好操作特征的两个$ r^2 $测量。我们通过分析弗雷明汉心脏研究中多种生活方式危险因素对环境暴露与冠心病和全因死亡率的环境暴露与时间之间关系的调解效应来说明$ r^2 $基于$ r^2 $的调解措施的实用性。
There is an increasing trend of research in mediation analysis for survival outcomes. Such analyses help researchers to better understand how exposure affects disease outcomes through mediators. However, due to censored observations in survival outcomes, it is not straightforward to extend mediation analysis from linear models to survival outcomes. In this article, we extend a mediation effect size measure based on $R^2$ in linear regression to survival outcomes. Due to multiple definitions of $R^2$ for survival models, we compare and evaluate five $R^2$ measures for mediation analysis. Based on extensive simulations, we recommend two $R^2$ measures with good operating characteristics. We illustrate the utility of the $R^2$-based mediation measures by analyzing the mediation effects of multiple lifestyle risk factors on the relationship between environmental exposures and time to coronary heart disease and all-cause mortality in the Framingham Heart Study.
