论文标题
随机动力网络的贝叶斯推断
Bayesian Inference of Stochastic Dynamical Networks
论文作者
论文摘要
网络推论已在系统生物学和社会科学等多个领域进行了广泛的研究。学习网络拓扑和内部动力学对于了解复杂系统的机制至关重要。特别是,稀疏拓扑和稳定的动态是许多现实世界连续时间(CT)网络的基本特征。鉴于通常只有一组节点能够观察到,在本文中,我们认为线性CT系统可以描绘网络,因为它们可以通过传输函数对未测量的节点进行建模。另外,测量值往往嘈杂,并且采样频率较低和不同。因此,我们考虑CT模型,因为离散时间近似通常需要细粒度的测量和均匀的采样步骤。开发的方法应用了源自线性随机微分方程(SDE)的动态结构函数(DSF)来描述测量节点的网络。一种数值抽样方法,预处理的曲柄 - 尼科尔森(PCN)用于完善粗粒轨迹以提高推理精度。开发方法的收敛属性对数据源的维度具有鲁棒性。蒙特卡洛模拟表明,开发的方法优于最先进的方法,包括稀疏贝叶斯学习(GSBL),宾果游戏,基于内核的方法,dyngenie3,genie3和arni。模拟包括随机和环网,以及合成生物网络。这些是具有挑战性的网络,表明可以在广泛的环境中应用开发的方法,例如基因调节网络,社交网络和通信系统。
Network inference has been extensively studied in several fields, such as systems biology and social sciences. Learning network topology and internal dynamics is essential to understand mechanisms of complex systems. In particular, sparse topologies and stable dynamics are fundamental features of many real-world continuous-time (CT) networks. Given that usually only a partial set of nodes are able to observe, in this paper, we consider linear CT systems to depict networks since they can model unmeasured nodes via transfer functions. Additionally, measurements tend to be noisy and with low and varying sampling frequencies. For this reason, we consider CT models since discrete-time approximations often require fine-grained measurements and uniform sampling steps. The developed method applies dynamical structure functions (DSFs) derived from linear stochastic differential equations (SDEs) to describe networks of measured nodes. A numerical sampling method, preconditioned Crank-Nicolson (pCN), is used to refine coarse-grained trajectories to improve inference accuracy. The convergence property of the developed method is robust to the dimension of data sources. Monte Carlo simulations indicate that the developed method outperforms state-of-the-art methods including group sparse Bayesian learning (GSBL), BINGO, kernel-based methods, dynGENIE3, GENIE3, and ARNI. The simulations include random and ring networks, and a synthetic biological network. These are challenging networks, suggesting that the developed method can be applied under a wide range of contexts, such as gene regulatory networks, social networks, and communication systems.