论文标题
肿瘤作为胚胎学现象及其对动物进化和癌症起源的影响。 iii。鞭毛细胞融合在第一动物的形成和沃堡效应的进化线索中的作用
The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. III. The role of flagellated cell fusion in the formation of the first animal and evolutionary clues to the Warburg effect
论文作者
论文摘要
细胞器与胚胎发育和进化的潜在相关性被低估了。从本文讨论的角度来看，Beroe Ovata中支持矿物化的statoliths和Macrocilia的梳子行和平衡器等结构表明，过去的多发性融合物中的过去事件。这些在进化史上独特的结构表明，早期动物以与源自Ctenophora的“发展计划”一致的方式处理基础体及其重复。此外，中心体扩增导致自发性肿瘤发生的事实表明，中心体调节过程被共同使用到肿瘤功能模块中。多叶氏菌，纤毛和鞭毛根源在动物和肿瘤的进化中。几个鞭毛的微型仪融合到具有随后的合子（单次）减数分裂阶段的细胞中，可能是动物进化和肿瘤过程的起源。在Ediacaran海洋中，我们还遇到了Warburg效应与肿瘤之间的进化联系。
Cytasters have been underestimated in terms of their potential relevance to embryonic development and evolution. From the perspective discussed herein, structures such as the multiciliated cells of comb rows and balancers supporting mineralized statoliths and macrocilia in Beroe ovata point to a past event of multiflagellate fusion in the origin of metazoans. These structures, which are unique in evolutionary history, indicate that early animals handled basal bodies and their duplication in a manner consistent with a "developmental program" originated in the Ctenophora. Furthermore, the fact that centrosome amplification leads to spontaneous tumorigenesis suggests that the centrosome regulation process was co-opted into a neoplastic functional module. Multicilia, cilia, and flagella are deeply rooted in the evolution of animals and Neoplasia. The fusion of several flagellated microgametes into a cell with a subsequent phase of zygotic (haplontic) meiosis might have been at the origin of both animal evolution and the neoplastic process. In the Ediacaran ocean, we also encounter evolutionary links between the Warburg effect and Neoplasia.
